Endocrine Abstracts

Background: Benign insulinomas are the most prevalent cause of endogenous hyperinsulinaemic hypoglycaemia (EHH) in adults and due to their small size difficult to localise. Until now, the most sensitive test to localize the area of the potential insulinoma was the intra-arterial calcium stimulation test, an invasive procedure with its associated risk. In contrast to the other neuroendocrine tumors, benign insulinomas do not exhibit upregulated somatostatin receptors sutype 2 (...

Introduction/Background: Gender differences affect the treatment of several diseases in both male and female patients. However, the influence of gender on treatment decisions and outcome in neuroendocrine neoplasms (NENs) has scarcely been investigated. Aims: Comparison of tumor characteristics, treatment decisions and outcome of patients with NENs, stratified by genderMaterial and Methods: Retrospective analysis of the SwissNET co...

Background: Epidemiologocal data suggest an continuous increase in thyroid carcinoma diagnosis. Therefore, thyroidectomy rates are projected to increase world-wide in exponential scale. In Switzerland, the institutional number of thyroidectomies varies, however there is no data yet on the association between institutional thyroidectomy volume and clinical outcome.Methods: Cross-sectional analysis of adult inpatients in Swiss hospitals using a nation-wide...

Background: Incidence of thyroidectomies and awareness to postoperative quality measures have both increased in the last decade. Gender-specific indications and variations in clinical outcomes of patients undergoing thyroidectomy in Switzerland are of interest.Methods: We cross-sectionally compared administrative nationwide patient-level data for length of hospital stay (LOS), intensive care unit (ICU) admission, 30-day readmissions rates, and other qual...

Introduction: Hypocalcemia has been linked to a decreased myocardial performance and even congestive heart failure, while acute chest-pain as leading symptom of hypocalcemia is an unusual presentation.Case report: A 29-year-old Caucasian man presented to the emergency department with relapsing chest-pain since several days, lasting seconds sometimes lasting several minutes, radiating to the left shoulder and combined with mild tingling in the neck. A det...

Background/introduction: SUB:Pituitary – Clinical (Generously supported by IPSEN)We have previously shown that GH assessment during a standardized aerobic exercise of moderate intensity is a reliable test with high diagnostic accuracy in predicting severe GH deficiency (GHD) in adult individuals. However, these studies comprised comparably long exercise durations around 60 min or longer. To improve clinical applicability of exercise testing in the diagnosis of GH...

Background: Glitazones (GZ) influence androgen biosynthesis in PCO syndrome. At present it is unknown whether a) steroid hormone metabolism is influenced by GZ in patients with type 2 diabetes b) there is a differential effect of RGZ and PGZ on steroid hormone metabolism c) this effect is sex-specific and d) this effect is mediated by changes in insulin sensitivity. Therefore, urinary steroid profiles and serum total testosterone and DHEA levels were analysed before and after ...

Introduction/ Background: Typical (TC) and atypical carcinoids (AC) are the most common neuroendocrine tumors (NETs) of the lung. Being a rare disease, the management of these tumors varies widely among Swiss centers. The impact of guidelines introduced in 2015 is unknown.Aims: Comparison of the management of Swiss patients before and after the publication of the expert consensus of the European Neuroendocrine Tumor Society (ENETS) in 2015.<p class="...

Purpose: The prevalence of pathological bone densities in men and women with prolactinomas treated either primary surgically or medically are infrequently reported across large cohorts. In the present study, we aimed at comparing the impact of either therapeutic approach on the bone density in men vs women with prolactinomas.Methods: Retrospective case-note study including all consecutive patients with prolactinomas in whom osteodensitometry data was ava...

Background: We and others have shown that ectopic lipids are flexible fuel stores in healthy subjects, in patients with type 1 diabetes or with GHD. IMCL are depleted by exercise and repleted by diet, whereas intrahepatocellular lipids (IHCL) are increased immediately after exercise. It is unclear whether the exercise-induced flexibility of IMCL and IHCL persists until 24 h and whether healthy subjects and patients with GHD behave differently.Methods: Ma...